<p>A-B Phospho-tau staining with AT8 (A) and AT180 antibody (B) revealed increased somato-dendritic accumulation of phosoho-tau in the cerebral cortex (A) and hippocampal CA1 layer (B) of hTau animals compared to wild-type (WT) and AICD-Tg transgenic mice at 3–4 mo of age. Scale bar = 100 μm C. Overexpression of human tau (hTau) increased pY1472-NMDAR levels in both WT and AICD animals. D. Quantification of pY1472-NMDAR/NMDAR levels in wild-type and AICD animals in the presence of mouse (mTau) or human tau (hTau). n = 5–6 for each genotype. *p<0.05, **p<0.01 one way ANOVA (Mean ± SEM). Sale bar in A,B = 50 μm.</p
