Abstract

<p>A) The majority of genes were ubiquitously expressed in the cortical surface areas of all four lobes of the brain. A small percentage of the genes were either distinctively expressed in one lobe or co-expressed in multiple but not all four lobes of the brain. The frontal lobe exhibits the most distinctively expressed genes. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006143#pgen.1006143.s006" target="_blank">S5 Table</a> for the lists of genes and locations. B) The distribution of functional annotations of the transcripts distinctively expressed in the frontal lobe. “All” indicates the distribution of all transcripts included in our analysis, irrespective of their expression levels and anatomical locations. There are a higher proportion of intergenic transcripts in the frontal lobe (22% compared to 14%). C) A gene network analysis for the frontal lobe (excluding intergenic transcripts). The yellow-colored genes belong to the most significantly associated pathway: interferon-gamma-mediated signaling pathway, related to immunity (FDR = 3.2 x10<sup>-4</sup>). Half of the genes were originally from the transcripts distinctively expressed in the frontal lobe. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006143#pgen.1006143.s008" target="_blank">S7 Table</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006143#pgen.1006143.s009" target="_blank">S8 Table</a> for the complete list of associated pathways.</p

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