<i>GAK</i> Gencode exons in the 3’ region are differentially expressed in PD.

Abstract

<p>(A) The mean normalized expression for PD cases and controls is plotted for each of the 71 <i>GAK</i> exon feature bins (x-axis). Exon 1 corresponds to the 3’ end of the gene, while Exon 71 corresponds to the 5’ end. Brackets indicate groups of exons significantly increased in PD relative to control (* = <i>q</i>-value < 0.05). (B) The mean normalized expression of <i>GAK</i> exon 25 (<i>GAK25</i>) is plotted for each stratified group. The samples are stratified by case status (Control and PD) and by genotype in an additive fashion (CC = Major allele homozygote, CT = Heterozygote, TT = Risk allele homozygote). (C and D) -ΔΔCT (log2 fold change) of <i>GAK</i> normalized to <i>PPIA</i> is plotted for all control and PD samples for (<b>c</b>) <i>GAK</i> 3’ exons and (<b>d</b>) <i>GAK</i> 5’ exons.</p