Functional type I and II interferons are expressed in response to secondary viral infection.

Abstract

<p>LCMV-immune mice were rechallenged with 2x10<sup>6</sup> PFU LCMV-Arm and (A) IFNα and (B) IFNγ levels in the plasma were assessed via ELISA or multiplex, respectively (n = 5 per time point). (C) Type I and type II ISG expression was quantified by PCR array in the spleens of LCMV-immune mice at 12 hours p.i., and the data were normalized to equivalent analyses of sham infected mice (sham n = 6, 12 hrs n = 4).</p

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