Abstract

<p>(A) <i>Experiment I</i>: RotaRod<sup>®</sup> performance test after early application of the IL-10 receptor blocking antibody (IL-10R Ab) at 0, 7, 14 and 21 dpi (arrows) revealed motor coordination deficits in TMEV-infected animals compared to mock-infected mice at 42 dpi. However, no differences were determined between IL-10R Ab- and isotype-treated animals. white box = TMEV-infected mice without IL-10R Ab treatment (group “isotype<sub>early</sub>/TMEV”), grey box = TMEV-infected mice with IL-10R treatment (group “IL10R↓<sub>early</sub>/TMEV”), black box = mock-infected mice with IL-10R treatment (group “IL10R↓<sub>early</sub>/mock”). (B) <i>Experiment II</i>: application of IL-10R Ab at 35 and 42 dpi (arrows) caused also deterioration of motor coordination starting at 42 dpi. However, no differences were observed between IL-10R Ab- and isotype-treated animals (groups “IL-10R↓<sub>late</sub>/TMEV” and “isotype<sub>late</sub>/TMEV”). white box = TMEV-infected mice without IL-10R Ab treatment (group “isotype<sub>late</sub>/TMEV”), grey box = TMEV-infected mice with IL-10R treatment (group “IL10R↓<sub>late</sub>/TMEV”), black box = mock-infected mice with IL-10R treatment (group “IL10R↓<sub>late</sub>/mock”). Box and whisker plots display median, minimum and maximum values as well as upper and lower quartiles, 5 animals used at all investigated time points, Wilcoxon rank-sum tests, *  =  p < 0.05.</p

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