Effect of brimonidine pretreatment on excitotoxically injured Brn3a+ RGCs.

Abstract

<p>Bar graphs showing survival of Brn3a+ RGC in retinas after NMDA injury pretreated with saline or brimonidine (BMD). Brn3a+ RGCs were counted using the automated cell counting in four retinal quadrants of flat-mount retina and survival is shown as percentage of the number of Brn3a+ cells in normal control retina (100%). Analysis of Brn3a+ cell survival at (A) 7 days and (B) 14 days post-lesion for each retinal quadrant and for the total retina. Cell counts are listed in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161862#pone.0161862.t002" target="_blank">2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161862#pone.0161862.t003" target="_blank">3</a>. One way ANOVA, Tukey’s post-hoc test, n = 4, * = p<0.05, ** = p< 0.01. D-T; dorso-temporal, D-N; dorso-nasal, V-N; ventro-nasal, V-T; ventro-temporal.</p

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