Leukocyte subsets in the colon of interleukin-10 receptor (IL-10R) neutralized SJL mice.

Abstract

<p>(A) Application of IL-10R antibody (Ab) leads to increased numbers of CD3⁺ T cells in the colon at all investigated time points. (B). An increase of CD45R⁺ B cells can be observed at day 21 after the first Ab application. (C) Foxp3⁺ regulatory T cells and (D) Iba-1⁺ macrophages are elevated at 7, 14, and 21 dpi. grey box with vertical lines = control animals (group “isotype”), white box with vertical lines = IL-10R blocked animals (group “IL-10R↓”). Box and whisker plot display median, minimum and maximum values as well as upper and lower quartiles, 5 animals used at all investigated time points, Wilcoxon rank-sum tests, *  =  p < 0.05.</p