Effect of dietary flavones on EZH2 catalytic activity and EZH2 and H3K27me3 protein expression.

Abstract

<p>(A) Dose-dependent inhibition of EZH2 catalytic activity measured through H3K27me3 with 10- μM and 20-μM concentrations of DZNep, Apigenin, Chrysin and Luteolin. The results are the mean of 3–4 determinations and were analyzed with a one way ANOVA, bars ± SD. **P<0.001. (B) Inhibition of EZH2 and H3K27me3 protein expression after treatment with 20 μM DZNep, Apigenin, Chrysin and Luteolin for 48 h. Anti-β-actin and anti-histone H3 were used as loading controls.</p

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