Number of enzyme targets for VMAT2 and TH.
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Abstract
<p>Optimal drug discovery considered with therapeutic, adverse, and variation effects simultaneously, at the specified number of enzyme targets. The left figure (A) is the case for 95% deficiency of VMAT2, and the right (B) for 100% deficiency of TH, whereas <i>u</i><sub><i>t</i></sub>, <i>u</i><sub><i>l</i></sub>, and <i>u</i><sub><i>d</i></sub> denote the external control for tyrosine, L-DOPA, and intracellular dopamine, respectively. Furthermore, α<sub><i>j</i></sub> is the enzyme activity for the <i>j</i><sup>th</sup> reaction rate.</p
