The genotype effect of rs2070600.

Abstract

<p>Serum sRAGE levels are lower in individuals with the C:T genotype at rs2070600 (p<0.0001, Mann-Whitney) (6i). Cells expressing RAGE-Ser82 (T allele) stimulated with HMGB1 for 48 hours had lower levels of sRAGE than RAGE-Gly82 (C allele) carrying cells (n = 4, p = 0.036), (6ii).</p