Evoked local potential recorded from lymph heart before and after addition of ZD7288 and effect of ZD7288 on lymph heart beating.

Abstract

<p>A) Representative trace of evoked local field potential (LFP) obtained from control and in the presence of ZD7288 (20μM) (B). C) Bar charts show average peak to peak of evoked LFP amplitude calculated from control and after adding ZD7288 (n = 11). The data for the evoked LFP in the presence of ZD7288 was normalised to data obtained from control. After adding ZD7288 the average peak to peak of evoked LFP amplitude was significantly reduced (*** p<0.001) compared to the control. Error bars represent mean ± SEM (n = 11). D) Representative trace obtained by plotting z-axis profile of lymph heart beating. The arrow on the left indicates the time at which ZD7228 is added. The lymph heart beating declined with time and eventually stopped beating completely as indicated on the trace.</p