<p>(A) Macroscopic appearance of splenic regenerates 8 weeks after implantation of wild-type splenic tissue (WT) into wild-type recipients (WT), LTβR deficient splenic tissue (LTβR<sup>-/-</sup>) into WT recipients, and WT splenic tissue into LTβR deficient recipients (LTβR<sup>-/-</sup>). (B) Weight (left side) and cell number (right side) of splenic regenerates. Indicated are means and standard deviation (n = 4–9, ** = p < 0.01). (C) Microscopic appearance of splenic regenerates. Cryostat sections were stained by immunohistochemistry for T cells (brown; TCRβ<sup>+</sup>) and B cells (blue; B220<sup>+</sup>). Red pulp (RP), T-cell zone (T), and B-cell zone (B) are well developed except in the LTβR<sup>-/-</sup> into WT combination where T and B cells are intermixed and only the red pulp (RP) is clearly recognizable (bar: 100 μm). This experiment was 3 times independently performed.</p
