<p>Peripheral nerve injury was caused by surgical maneuver, e.g., tooth extraction, and it invaded the inferior alveolar nerve, inducing local diffusion of BDNF at the lesion. BDNF stimulated the differentiation of osteoblasts through trkB receptor, resulting in sclerotic changes in the bone. As a result, osteogenesis and remodeling over the bone cavity wall were facilitated, making the wall thicker and resulting in isolation of the surrounding alveolar tissue. OB, osteoblast; OS, osteocyte; OC, osteoclast; IAN, inferior alveolar nerve.</p
