Assessment of the precision of clonal frequency estimation.

Abstract

<p><b>(A)</b> Point estimates of clonal abundances generated by alphabetr, derived from representative simulations using five plates and distributions with 25 and 5 clones in the top 50% (left and right panels respectively). (B) The coefficient of variation (precision) of abundance estimates for a range of skewnesses of clone sizes and sampling strategies. Values quoted are averages over 100 simulations.</p

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