Estrogenic gene expression profiles of lignans revealed by DNA microarray assay.

Abstract

<p>Correlation of gene expression profiles was examined between individual pairs of E₂ and lignans. The gene expression profiles for these chemicals were compared using a set of 150 estrogen-responsive genes in scatter-plot graphs. The vertical and horizontal axes indicate log₂ values of the signal intensities. <i>R</i>- and <i>p</i>-values were calculated for each graph on the basis of linear regression between two profiles.</p