Numerical simulation of oxygen uptake by lipofuscin in paramacular RPE in-vivo during exposure to diffuse sunlight.

Abstract

<p>Oxygen uptake was calculated based on results from a previous investigation of oxygen uptake by isolated human lipofuscin granules [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172635#pone.0172635.ref020" target="_blank">20</a>], after correction for factors affecting retinal exposure levels in-vivo (see text). Results were plotted for healthy people of different ages: 20-year old (red), 40-year old (green), and 60-year old (orange). Results for 20-year old patients with STGD1 are also shown (grey).</p