Light attenuation by RPE-melanin in-vivo varies with age and the presence of Stargardt disease.

Abstract

<p>We calculated the total optical density (OD) of paramacular RPE-melanin versus wavelength of incident radiation with Eqs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172635#pone.0172635.e004" target="_blank">4</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172635#pone.0172635.e006" target="_blank">6</a> based on results of Monte-Carlo simulations. Colored lines indicate attenuation in healthy people of different ages: 20 (red), 40 (green), and 60 (orange). The same is shown for a 20-year old patient with STGD1 (black).</p