a novel computational framework was designed,
whereby important network topological properties of melanoma genes were first investigated.
The analysis demonstrated that
melanoma genes can modulate its activity by changing network connections
independent of its expression profile. Most
of such genes consistently rewired their connections in different melanoma
networks as compared to the control network. Intriguingly,
the genes which rewired its connections in multiple stages of melanoma were more
conserved than the genes with differential expression
