The lack of helix C in β-catenin does not prevent interaction with ICAT.

Abstract

<p><b>A</b>. Schematic representation of WT and mutant Δ665 HA-tagged β-catenin-NLS proteins. <b>B</b>. Total cell lysates from Lu1205 cells transfected with WT or mutant β-catenin Δ665 were analyzed by WB or affinity immunoprecipitated with WT ICAT-GST recombinant protein and blotted with anti-HA and anti-ICAT antibodies. Numbers represent mean ± SD of normalized densitometry values from three independent experiments, *p<0.05.</p

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