<p>Two new sesquiterpene lactone glycosides, namely melitensin 15-<i>O</i>-<i>β</i>-D-glucoside (<b>1</b>) and 11<i>β</i>,13-dihydrosalonitenolide 15-<i>O</i>-<i>β</i>-D-glucoside (<b>2</b>), along with eight known compounds (<b>3–10</b>) were isolated from the aerial part of <i>Cnicus benedictus</i> L. Their structures were elucidated from analyses of extensive spectroscopic data. Compounds <b>1–6</b> all possessed an <i>α</i>-methyl-<i>γ</i>-lactone moiety. Moreover, compound <b>5</b> exhibited moderate activity against the growth of <i>Aspergillus fumigatus</i>, with IC<sub>50</sub> values of 17.67 μg mL<sup>−1</sup>.</p
