Pd-Catalyzed Regioselective
Mono-Arylation: Quinazolinone
as the Inherent Directing Group for C(sp<sup>2</sup>)–H Activation
- Publication date
- Publisher
Abstract
The
Pd-catalyzed quinazolinone-directed regioselective monoarylation
of aromatic rings by C–H bond activation is developed. A broad
substrate scope is demonstrated for both quinazolinone as well as
diaryliodonium triflates. The use of a base was found to be crucial
for this transformation, unlike for the known nitrogen-directed arylations.
All of the novel quinazolinones of biological interest were synthesized
by using the operationally simple Pd(II)-catalyzed arylation reaction