Additional file 1: Table S1. DAZT intervention components according to activity in Gujarat

Amnesty LeFevre (3432068)

Christa Fischer-Walker (4098691)

Robert Black (412336)

Samuel Shillcutt (4098685)

Sarmila Mazumder (758661)

Sunita Taneja (715243)

Cost Effectiveness and Resource Allocation

Abstract Background This study evaluates the cost-effectiveness of the DAZT program for scaling up treatment of acute child diarrhea in Gujarat India using a net-benefit regression framework. Methods Costs were calculated from societal and caregivers’ perspectives and effectiveness was assessed in terms of coverage of zinc and both zinc and Oral Rehydration Salt. Regression models were tested in simple linear regression, with a specified set of covariates, and with a specified set of covariates and interaction terms using linear regression with endogenous treatment effects was used as the reference case. Results The DAZT program was cost-effective with over 95% certainty above $5.50 and $7.50 per appropriately treated child in the unadjusted and adjusted models respectively, with specifications including interaction terms being cost-effective with 85–97% certainty. Discussion Findings from this study should be combined with other evidence when considering decisions to scale up programs such as the DAZT program to promote the use of ORS and zinc to treat child diarrhea

Samuel D. Shillcutt

Amnesty E. LeFevre

Christa L. Fischer-Walker

Sunita Taneja

Robert E. Black

Sarmila Mazumder

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Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

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MOESM1 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

Additional file 11: Table S5. Net benefit of the DAZT program relative to status quoâmultivariable regression with interaction terms with Rheingans et al. [30] set of interaction terms: ORS and zinc coverage as effectiveness measure

MOESM11 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

Additional file 2: Table S2. Hypotheses about variables

MOESM2 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

Additional file 4: Figure S1. Adjusted cost-effectiveness acceptability curves using the full set of covariates

MOESM4 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

Additional file 6: Figure S2. Adjusted cost-effectiveness acceptability curves with interaction terms using the full set of covariates

MOESM6 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

Additional file 3: Table S3. Adjusted net benefit of the DAZT program relative to (baseline) conditions existing before the program using the full set of covariates and ORS and zinc coverage as the effectiveness measure 1

MOESM3 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

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MOESM1 of Cost-effectiveness analysis of the diarrhea alleviation through zinc and oral rehydration therapy (DAZT) program in rural Gujarat India: an application of the net-benefit regression framework

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