Enantioselective Conjugate Addition of 2‑Acetyl Azaarenes to β,β‑Disubstituted Nitroalkene for the Construction of All-Carbon Quaternary Stereocenters

Abstract

The first highly enantioselective conjugate addition of 2-acetyl azaarenes to α-substituted-β-nitro­acrylates was successfully realized under mild conditions by a Ni­(II)-bisoxa­zoline complex, providing the desired adducts bearing an all-carbon quaternary stereocenter in high yield with excellent enantioselectivity. The products obtained in this system could be readily converted into optically active β^2,2-amino esters, succinates, lactones, and lactams