EZM analysis of at 11–13 months of age (middle aged).

Abstract

<p>Age- and strain-matched WT (n = 17) mice were evaluated in parallel with NrbKO (n = 8) and SpKO (n = 9) mice. (A) The percentage of time spent in the open and closed area of EZM over the total trial time. (B) Total distance traveled during the EZM trial. (C) Entries into the open and closed area of EZM during the trial. Data are mean ± SEM. **, <i>p</i><0.01; ***, <i>p</i><0.001, SpKO <i>vs</i>. WT by Student’s <i>t</i> test.</p