<p></p> <p>We report herein a novel and efficient method for iron-catalyzed aerobic oxidative phosphonation of <i>N</i>-aryl tetrahydroisoquinolines for the synthesis of biologically interesting α-aminophosphonates. This new C–P bond formation reaction features the employment of a sustainable and cost-effective iron salt [Fe(NO<sub>3</sub>)<sub>3</sub>·9H<sub>2</sub>O] as catalyst, the utilization of air as environmental-benign oxidant, as well as the user-friendly open-flask reaction conditions.</p
