Additional file 1: Figure S1. HPLC analysis of CsA and [(4’-OH)MeLeu]4-CsA. Figure S2. NMR analysis of CsA and [(4’-OH)MeLeu]4-CsA. Figure S3. HRMS analysis of CsA and [(4’-OH)MeLeu]4-CsA. Figure S4. 2DE-based proteomic profiles of N. dietziae. Proteins are extracted at different growth phases and media. Arrows point to the significantly differential proteins under MO condition and their characteristics are shown in Table 1. Table S1. Primers for qRT-PCR of the CYPs