Proteasome-mediated degradation plays a role in STING reduction.

Abstract

<p>(A) Time course assessment of STING mRNA expression after MRC-5 cells were transfected with pcDNA3.1 (0.05μg). (B) Western blotting assessment of STING after MRC-5 cells were transfected with pcDNA3.1 (0.05μg) with treatment of Bortezomib (20 nM) or DMSO for 18h. (C)Western blotting assessment of immunoprecipitated STING with anti-ubiquitin antibody.</p