The LDCs affect the functional segregation and integrations.

Abstract

<p>(A) Hierarchical tree of the real <i>macaque</i> cortical network. The color of dots represents the corresponding function (visual: red, somatosensory: green, motor: blue, temporal: pink and frontal: black). The red stars indicate the 6 core special areas of LDCs, and the blue stars for the rest 6 LDCs. (B) Spatial distribution of different sub-trees in the real network mapped on the cortical surface using BrainNet Viewer [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005776#pcbi.1005776.ref081" target="_blank">81</a>]. The LDCs in the sub-trees are shown as big balls with connections among each other. (C, D, E) Hierarchical modular organization of the cortical connectome, the reconstructed network at α = 0.006, and a randomized network (‘R-network’), respectively. Every pie in (C), (D) or (E) represents a hierarchical sub-tree (connectivity module) dominated by areas of a certain functional modality (matching ratio > 50%) in the corresponding network. The number of areas is listed next to the tree. The areas not involved in any hierarchical tree are combined into the “non-cluster” pie. The colors in the pie represent different functional systems (as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005776#pcbi.1005776.g003" target="_blank">Fig 3B and 3A</a>), and the corresponding ratios of these systems in a given hierarchical sub-tree are listed. The original LDCs belonging to different sub-tree or non-cluster groups are shown by stars. These areas are grouped together by light solid lines with a diamond shape for the real network (C), by the shape of the circle in the reconstructed network (D), or by the shape of a hammer in the R-network (E). The arrows from the group of the special areas indicate the distribution of the links of this group to other sub-trees, with the ratio listed by bold fonts near the corresponding arrows.</p