TLR2/TLR4 regulate <i>F</i>. <i>nucleatum</i>-induced inflammatory cytokines through Tregs in vivo.

Abstract

<p>(A, B and C) Production of IL-8, IL-1β and TNF-α in C57BL/6 wild-type mice and in hybrid, TLR2<sup>-/-</sup> and TLR4<sup>-/-</sup> mice infected with <i>F</i>. <i>nucleatum</i> for 1 week, as assessed by enzyme-linked immunosorbent assay (ELISA). (D) The number of <i>F</i>. <i>nucleatum</i> 16s rRNA gene copies in the gastric mucosa of C57BL/6 wild-type mice and in hybrid, TLR2<sup>-/-</sup> and TLR4<sup>-/-</sup> mice determined by qRT-PCR. (E) After transfer of Tregs from wild-type mice to TLR2<sup>-/-</sup> mice, the production of IL-8, IL-1β and TNF-α in TLR2<sup>-/-</sup> mice infected with <i>F</i>. <i>nucleatum</i> for 1 week and in the uninfected group was assessed by ELISA.</p

    Similar works

    Full text

    thumbnail-image

    Available Versions