TLR2/TLR4 signaling modulates <i>F</i>. <i>nucleatum</i>-induced inflammation in vivo.
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Abstract
<p>(A) Histological inflammation scores (H&E staining) of the gastric mucosa of C57BL/6 wild-type mice and TLR2<sup>-/-</sup> and TLR4<sup>-/-</sup> mice with <i>F</i>. <i>nucleatum</i> infection for 1 week. The intensity of staining is shown in the right graph, and the data are expressed as the mean±SEM. (B) The body weight of C57BL/6 wild-type mice and TLR2<sup>-/-</sup> and TLR4<sup>-/-</sup> mice after <i>F</i>. <i>nucleatum</i> infection. (C, D and E) The production of IL-8, IL-1β and TNF-α in C57BL/6 wild mice and TLR2<sup>-/-</sup> and TLR4<sup>-/-</sup> mice infected with <i>F</i>. <i>nucleatum</i> for 1 week, as assessed by enzyme-linked immunosorbent assay (ELISA). (F) The number of <i>F</i>. <i>nucleatum</i> 16s rRNA gene copies in the gastric mucosa of C57BL/6 wild mice and TLR2<sup>-/-</sup> and TLR4<sup>-/-</sup> mice based on qRT-PCR.</p