Base-Mediated Three-Component Tandem Reactions for the Synthesis of Multisubstituted Pyrimidines

Abstract

A base-mediated three-component tandem reaction for the synthesis of multisubstituted pyrimidines from amidines, aryl alkynes, and aldehydes in a one-pot manner has been developed. Advantages of this transformation include being transition-metal-free, high efficiency, available starting materials, and being environmentally friendly