Cellulose-Based Composite Macrogels from Cellulose
Fiber and Cellulose Nanofiber as Intestine Delivery Vehicles for Probiotics
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Abstract
Cellulose-based
composite macrogels made by cellulose fiber/cellulose
nanofiber (CCNM) were used as an intestine delivery vehicle for probiotics.
Cellulose nanofiber (CNF) was prepared by a 2,2,6,6-tetramethylpiperidine-1-oxyl
radical (TEMPO)-mediated oxidation system, and the carboxyl groups
in CNF acted as pore size and pH responsibility regulators in CCNMs
to regulate the probiotics loading and controlled release property.
The macrogel presented a porosity of 92.68% with a CNF content of
90%, and the corresponding released viable <i>Lactobacillus plantarum</i> (<i>L. plantarum</i>) was up to 2.68 × 10<sup>8</sup> cfu/mL. The porous structure and high porosity benefited <i>L. plantarum</i> cells to infiltrate into the core of macrogels.
In addition, the macrogels made with high contents of CNF showed sustainable
release of <i>L. plantarum</i> cells and delivered enough
viable cells to the desired region of intestine tracts. The porous
cellulose macrogels prepared by a green and environmental friendly
method show potential in the application of fabricating targeted delivery
vehicles of bioactive agents