Effects of Polyacrylonitrile/MoS₂ Composite Nanofibers on the Growth Behavior of Bone Marrow Mesenchymal Stem Cells

Abstract

In recent years, molybdenum disulfide (MoS₂) as a typical class of two-dimensional (2D) materials has attracted wide attention because of its various fascinating properties. In this study, we fabricated MoS₂ composite nanofibers by electrospinning technology combined with a doping method. The as-prepared MoS₂ composite nanofibers exhibited excellent biocompatibility. In addition, the detailed investigation about the response of MoS₂ composite nanofibers on bone marrow mesenchymal stem cells (BMSCs) indicated that the obtained MoS₂ composite nanofibers could promote BMSC growth behavior, improve BMSC contact with each other, maintain cellular activity, and also provide positive promotion to regulate cellular proliferation. Moreover, the alkaline phosphatase expression significantly increased with increasing MoS₂ concentration. Compared with the excellent biocompatibility and natural extracellular-matrix-like structure, we believe that the MoS₂ composite nanofibers could provide new insight for the preparation of well-defined MoS₂ nanostructure materials and will have promising potential in biomedical applications, such as tissue engineering, photothermal therapy, etc