DJ-1 knockout mice had impaired performance on running wheels and on the Rotarod but normal cognitive and exploratory activity.

Abstract

<p>Ten months old homozygous DJ-1 knockout (DJ-1 KO) mice and C57BL/6 wild-type (WT) littermates were trained to perform running wheel exercise in their individual cages. Daily running distances were recorded for two weeks. (<b>A</b>) Wild-type mice ran 5.57 ± 0.21 miles per day, while DJ-1 knockout mice were significantly slower, running 0.89 ± 0.06 miles per day (n = 6, multi-variance ANOVA test, **<i>p</i><0.01). Ten months old DJ-1 knockout mice and C57BL/6 wild-type littermates were also tested on the Rotarod (<b>B</b>), Morris water maze (<b>C</b>), and open field (<b>D</b>). (<b>B</b>) DJ-1 knockout mice fell from the Rotarod after a shorter period of time than WT mice when tested at 20 and 26 rpm (n = 6, multi-variance ANOVA, F<sub>(4, 60)</sub> = 16.93, <i>p</i> = 0.0089, *<i>p</i><0.05, **<i>p</i><0.01). (<b>C</b>) DJ-1 knockout mice and WT littermates had similar learning curves in the Morris water maze (n = 6, multi-variance ANOVA, <i>p</i>>0.1). (<b>D</b>) DJ-1 knockout mice and WT mice had similar exploratory activity in open field testing (n = 6, multi-variance ANOVA, <i>p</i>>0.1).</p

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