Chronic CORT exacerbates LPS-induced neuroinflammation brain wide.
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Abstract
<p>The effects of chronic CORT pretreatment (200 mg/L 0.6% EtOH in drinking water for one week) on LPS (2 mg/kg, s.c.)-induced TNFα, IL-6, CCL2, IL-1β, LIF, and OSM mRNA levels were measured in samples prepared from cortex (CTX), hippocampus (HIP), striatum (STR), hypothalamus (HYPO), olfactory bulb (OB), and cerebellum (CB) 6 hours after LPS exposure. Data represents mean ± SEM (n = 5 mice/group). Statistical significance of at least p<0.05 is denoted by * as compared to control, # as compared to LPS alone.</p