Chronic CORT sensitizes the CNS to a sub-neuroinflammatory inhalation dose of LPS.

Abstract

<p>Mice pretreated with CORT (200 mg/L 0.6% EtOH in drinking water for one week) were subjected to 3 hours of LPS (7.5 μg/m<sup>3</sup>) by inhalation. TNFα, IL-6, CCL2, IL-1β, LIF, and OSM mRNA levels were measured in samples prepared from cortex collected immediately following LPS inhalation exposure. Data represent mean ± SEM (n = 5 mice/group). Statistical significance of at least P<0.05 is denoted by * as compared to respective control and # as compared to LPS alone exposed group.</p

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