SOX10 post-translational modifications identified in MG132-treated 501mel cells.

Abstract

<p>This schematic representing the SOX10 protein indicates known domains, SOXE conserved regions, and phosphorylated residues, as follows: black bars show known phosphorylation sites, green bars show known sites that were confirmed in this study, and red bars show novel sites from this study. The phosphorylated residues S224, S232, T240 and T244 were observed on numerous peptide fragments, and one or all four are plausible; their close proximity and the limited fragmentation capability in the digest restrict more precise determination among these residues. The nuclear localization and nuclear export signal regions are unaffected by the phosphorylation sites.</p

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