Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study - Fig 3

Abstract

<p>(A) Community analysis. Correlated motion of the sub-domains in the glycosylated and non-glycosylated forms of proMMP-9. Sub-domains that are moving together are represented in the same color. (B) Left and right panel represents the comparison of RMSDs of the pro and catalytic domains of glycosylated proMMP-9 and Gal-8N domain and the solvent-accessible surface area (SASA in Ų) of two proteolytic fragments for the complex composed of Gal-8N and glycosylated proMMP-9, respectively. (C) Structural model of the complex composed of Gal-8N and proMMP-9.</p