Copper-Catalyzed Aza-Michael
Addition of 2‑Aminobenzoate
to β‑Substituted α,β-Unsaturated Ketones:
One-Pot Synthesis of 3‑Carbonyl-2-Substituted Quinolin-4(1<i>H</i>)‑ones
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Abstract
We present a new
and straightforward one-pot process for the synthesis
of 3-carbonyl-4-quinolone derivatives through highly efficient Cu-catalyzed
aza-Michael addition of 2-aminobenzoates to β-substituted α,β-unsaturated
ketones/cyclization/mild oxidation reactions. A broad range of new
versatile 3-carbonyl-quinolin-4(1<i>H</i>)-ones is prepared
from readily available chemicals under mild reaction conditions with
short reaction times, producing good to excellent yields (up to 99%)