Bogaerts, Ria

D'agostino, Emiliano

Vande Velde, Greetje

Vanhove, Christian

English

Ghent University Academic Bibliography

From: EMIM 2017 abstract@eventclass.comSubject: Abstract transmission report | EMIM late-breaking abstract 2017Date: 22 February 2017 at 23:41To: Greetje Vande Velde greetje.vandevelde@kuleuven.beCc: Emiliano D'agostino emiliano.dagostino@dosevue.com, Christian Vanhove Christian.Vanhove@UGent.beDear Prof. Dr. Vande VeldeYou have successfully submitted your abstract for the EMIM 2017.This is the transmission report. You can make changes on your submission until thedeadline. To modify your submission you need to log in to the control center. The logindata for the control center has been sent to the corresponding author in a separate e-mail.Your registration: With the submission of a late-breaking abstract you are entitled toregister for the early bird fee. Deadline for early bird registration was February 14,2017. In case you have not registered yet, please enter your individual reduction coded2017JUSze during your online registration. This code is valid until March 27, 2017.Registration is possible via www.emim.eu.In case you are not the presenting author of this submission please forward the codeto the presenting author.Looking forward to meeting you in Cologne. For further information on programme,speaker, travel... www.emim.eu.Data:ID:  #516Topic:  Imaging Technology, Methodology & Data Analysis >Nuclear and CT ImagingType of presentation:  Oral or Poster presentationKeywords:  dosimetry, micro-CT, radiotherapy   Authors:   Main author:  D'agostino EmilianoPresenting author:  D'agostino EmilianoCorrespondenceauthor:  Vande Velde GreetjeAuthors including incorrespondence:  D'agostino Emiliano, Vanhove ChristianAccess rights*:  Vande Velde Greetje<greetje.vandevelde@kuleuven.be>*This author already has access rights for control center or the access data were sentautomatically by the system to this author. Your submission:DoseWire: optical fiber-based real-time dosimetryfor microCT and radiation therapy applicationsIntroductionD'agostino Emiliano1, Bogaerts Ria2, Vanhove Christian3, Vande Velde Greetje41DoseVue NV - Mol, Belgium2Laboratory of Experimental Radiotherapy, Oncology - Leuven, Belgium3Institute Biomedical Technology, Medical Imaging and Signal Processing - Gent, Belgium4Biomedical MRI/ MoSAIC, Imaging and Pathology - Leuven, BelgiumIntroductionIonizing radiation is frequently used in pre-clinical research for diagnostic andtherapeutic purposes. Radiation based imaging, such as micro-computed tomography(µCT) is a powerful tool for non-invasive longitudinal follow-up of animal models. A lotof interest has also been directed towards the optimization of small animal radiationtherapy (SmART), for subsequent translation to patients. In both cases (imaging andtherapy), the animal models involved in the studies may be exposed to significantamounts of radiation. Therefore, an accurate monitoring of radiation doses is crucial toavoid excessive exposure of healthy tissues.DoseWire is a dosimetry device based on an optical fiber, allowing real-time radiationmonitoring. The device is portable and user-friendly and can also be used within amouse for in-situ measurements in a minimally invasive way. DoseWire ischaracterized by an elevated signal to noise ratio and can therefore be used withoutneed of corrections for the so-called stem effect [1]. This is particularly importantwhen using large irradiation fields (as in imaging) and/or when the beam axis is closeto 45°.MethodsDoseWire was used with a small animal µCT (SkyScan 1076, 1276 and 1278, BrukermicroCT, Kontich, Belgium) and on a small animal irradiation platform (SARRP, Xstrahl,Surray, UK). Measurements on the µCT were performed for different protocols(changing mAs, kV (35-70 kV range) and filter combinations) and scanner types.Measurements on the SmART system were all performed at 220keV using differenttube currents (dose rates). In all cases, DoseWire was calibrated by an ionizationchamber.ResultsThe graph below shows a linearity test for measurements performed on a SmARTsystem, demonstrating that the response of the DoseWire is linear within a broadrange of dose rates. Measurements were reproducible with a variability below 1-2%.DoseWire was also tested on imaging fields, using different protocols covering a broadrange of microCT imaging applications on different scanner types. DoseWire allowedreal-time feedback on the effect on dose rate when changing scan parameters (tubecurrent, filter type, kV), thereby allowing optimization of scan settings in function ofminimal dose. Reproducibility of the measured dose within the FOV, to the animal andto organs was found to be excellent.ConclusionsReal-time dose measurements are an important asset when performing studiesinvolving intensive use of ionizing radiation, either for imaging purposes, or fortherapy studies. In both cases, monitoring the dose in real-time can contribute tooptimized experimental protocols, thereby allowing to maximize the quality of thestudy and to prevent over-exposure of tissues, possibly leading to significantexperimental bias. DoseWire proved to be an accurate and user-friendly tool forsystematic real–time dose monitoring in different experimental conditions. [1] On the nature of the light produced within PMMA optical light guides in scintillation fiber-opticdosimetry, Therriault-Proulx et al. Phys. Med. Biol. 58 2073Figure 1:Best regardsYour EMIM 2017 abstract management teamScientific contact:ESMI - European Society for Molecular ImagingManagement OfficeDoris Krachtphone: +49 221 78966180e-mail: office@e-smi.euTechnical support:EventClass GmbHphone: +49 351 30900031e-mail: abstract@eventclass.comFigure 1:DoseWire

DoseWire: optical fiber-based real-time dosimetry for microCT and radiation therapy applications

https://biblio.ugent.be/publication/8544284/file/8544285.pdf

DoseWire: optical fiber-based real-time dosimetry for microCT and radiation therapy applications

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