"Optimal organismal function and survival in adverse conditions require robust
homeostatic responses to challenging environmental conditions. Surviving a
severe infection requires the synergy between resistance and disease
tolerance, two evolutionarily conserved defense strategies that limit disease
severity. Sepsis – a dysregulated host response to infection that leads to high
risk of death – is a prime example of extreme homeostasis disruption and
therefore constitutes an excellent model to study homeostasis and inter-organ
communication principles.(...)
