Work satisfaction and turnover intention are two important aspects regarding human resource in health service. The research was aimed to analyze the impact of individual, job and organizational factors on jobsatisfaction and turnover intention of nurses in the clinic “Balai Pengobatan Santa Familia” (BPSF), East Kalimantan. The research applied analytical observation method. Data were collected by interviewing nurses in the intensive care unit and in the nursing unit of BPSF. The research showed that most nurses was still in young age but with low commitment and high turnover intention. The workload and conflicts in BPSF was high. Moreover the work affiliation, compensation and work development tend to be low. This caused a low work satisfaction and high turnover intention. Through the application of the double linear regression statistic test, job design has significant impact on job satisfaction (Sig. 0,013, regression coefficient 2,037). The work affiliation and leadership have significant influence to turnover intention (Sig. 0,003, regression coefficient 0,906) as well as leadership (sig. 0,009, regression B= 0,895). This study concluded that job design and leadership had significant impact on job satisfaction and turnover intention. Meanwhile work affiliation did not impact both of them.Keywords: individual, job satisfaction, organizational, turnover intentio