: Infestation of soil transmitted helminth is often found among communities in developing countries. This helminthic infestation can affect nutritional state, physical growth, mental, cognition, and intellectual deterioration in children. Increased eosinophils (eosinophilia) is often associated with diseases caused by worms and allergy. This study aimed to determine the links between investastion of soil transmitted helminth and esinophilia among students in SD GMIM Buha Manado. This was a prospective observational study with a cross-sectional approach. According to exclusive and inclusive criteria, 80 samples were obtained. Data were analyzed by using the Fisher Exact and Phy correlation coefficient analysis. The resluts showed that 17.5 % students were infected by Ascaris lumbricoides, meanwhile Trichuris trichiura and hookworm were not evident. The corelation test showed that there was a significant relationship between infestation of soil transmitted helminth and eosinophilia with a P-value = 0.001. Conclusion: There was a high significant relationship between infestation of soil transmitted helminth and eosinophilia among students of SD GMIM Buha Manado. The most frequent found was Ascaris lumbricoides and its infestation was marked by eosinophilia