Bacterial pathogens have coevolved with their hosts and acquired strategies to
circumvent defense mechanisms of host cells. It was shown that bacteria
interfere with the expression of mammalian microRNAs to modify immune
signaling, autophagy, or the apoptotic machinery. Recently, a new class of
regulatory RNAs, long non-coding RNAs (lncRNAs), was reported to have a
pivotal role in the regulation of eukaryotic gene expression. A growing body
of literature reports on specific involvement of lncRNAs in the host cell
response toward bacterial infections. This mini review summarizes recent data
that focuses on lncRNA function in host cells during bacterial infection and
provides a perspective where future research in this regard may be going
