类固醇激素受体辅激活子3（Steroidreceptorcoactivator,SRC-3）是一种转录协同因子，它能够与多种核受体及其它转录因子相互作用而增强它们的转录活性。我们以前的研究表明由于SRC-3敲除导致过度的炎症反应和巨噬细胞清除细菌能力的损伤，SRC-3-/-小鼠对大肠杆菌诱导的腹膜炎更敏感，说明SRC-3在宿主防御细菌感染中起着重要作用。最近，我们发现SRC-3在结肠上皮细胞中特异性高表达，并且在小鼠感染Citrobacterrodentium后小鼠结肠中SRC-3蛋白量显著上调，说明SRC-3可能参与宿主防御A/E细菌感染。本研究中，我们通过比较SRC-3-/-小鼠和野生型小...Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator which interacts with nuclear receptors and other transcription factors to enhance their effects on target gene transcription. Previously, we reported that SRC-3-deficient (SRC-3-/-) mice were markedly more susceptible to E. coil-induced septic peritonitis due to an uncontrolled overwhelming inflammation and a defect in bacteri...学位：理学博士院系专业：生命科学学院_细胞生物学学号：2162012015379
