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Generation and Characterization of HCMV Specific Human Antibody to Explore Antibody Response Profile in HCMV Naturally Infected Individuals

Abstract

人巨细胞病毒(Humancytomegalovirus,HCMV)是一种常见的疱疹病毒,在人群中普遍感染,儿童感染率约为10%-40%,成人为50%-90%,大部分感染者为无临床症状的健康人。但机体免疫功能低下的人群如器官移植患者及AIDS病人,更易发生HCMV病毒的新发或复发感染,引起致命疾病如肺炎、肝炎、脑炎等,从而导致器官移植失败及术后死亡;同时HCMV病毒也是宫内感染中危害最大的病毒之一,感染率占怀孕妇女的0.5%-2%,尤其是在发展中国家较为常见,孕妇感染后自身多无明显症状或轻微症状,但是病原体可以通过胎盘传染给胎儿,引起死胎、早产、流产或胎儿先天性神经管缺陷,因此HCMV的预防及治...Human cytomegalovirus (HCMV) is one of the most common and challenging herpesvirusesin the world, it infects a large proportion of the human population (50-90% among adults and 10-40% among children) including immunocompromised patients especially for transplant recipients with immune suppression, causes severe diseases such as pneumonia, hepatitis, encephalitis and remains a risk factor for trans...学位:理学博士院系专业:生命科学学院_生物化学与分子生物学学号:2162010015389

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