SKA2 gene � A novel biomarker for latent anxiety and preterm birth prediction

Abstract

Background: There is a relationship between preterm birth (PTB)and anxiety. Spindle and Kinetochore Associated Complex Subunit 2 (SKA2)gene polymorphism (NC000017.11: g.59110368 G > A)has also been associated with the development of anxiety. The current study was designed to evaluate the relationship between SKA2 gene SNP (NC000017.11: g.59110368 G > A)with the occurrence of anxiety and PTB which might be considered a predictive biomarker for the prediction of preterm delivery. Methods: SKA2 gene (SNP rs7208505)genotyping was performed in 300 women with term birth (TB)and 293 women with PTB using PCR-RFLP method and then followed by DNA sequencing. Cortisol level was analyzed with ELISA method and the presence of anxiety was detected using Spielberg Inventory. Results: The AA genotype of SKA2 gene significantly increased the risk of PTB compared to the GG genotype by 9.6 fold (CI4.5�20.2, P A)could be as a predictive biomarker for the risk of PTB. © 2019 Elsevier B.V