Scaffolds (artificial ECMs) play a pivotal role in the process of regenerating tissues in 3D. Biodegradable synthetic polymers are the most widely used scaffolding materials. However, synthetic polymers usually lack the biological cues found in the natural extracellular matrix. Significant efforts have been made to synthesize biodegradable polymers with functional groups that are used to couple bioactive agents. Presenting bioactive agents on scaffolding surfaces is the most efficient way to elicit desired cell/material interactions. This paper reviews recent advancements in the development of functionalized biodegradable polymer scaffolds for tissue engineering, emphasizing the syntheses of functional biodegradable polymers, and surface modification of polymeric scaffolds. Significant efforts have been made to develop functional biodegradable scaffolds for tissue regeneration that can enhance cell function and guide new tissue formation. This paper discusses the recent advancements of functionalizing synthetic biodegradable polymer scaffolds, focusing on polymer synthesis, surface modification, and cellular response on these functionalized scaffolds.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92034/1/911_ftp.pd
