GLYCEMIC CONTROL IN DIABETES MELLITUS PATIENTS WITH CHRONIC KIDNEY DISEASE – HOW TO CHOOSE HYPOGLYCEMIC AGENT?

Abstract

Liječenje hiperglikemije kod bolesnika s kroničnom bubrežnom bolešću je kompleksno, a ciljevi i načini postizanja glikemijske kontrole nisu jasno definirani. Iako je agresivno sniženje hiperglikemije korisno u ranim stadijima dijabetičke nefropatije, podatci o jasnoj koristi ovakvog liječenja u uznapredovaloj bubrežnoj bolesti nedostaju. Poseban izazov u liječenju ovih bolesnika su zahtjevne i učestale kontrole koje su neophodne kod ovih bolesnika, ali i kompleksnost dostupnih metoda liječenja. U ovom osvrtu učinjen je pregled svih trenutno dostupnih hipoglikemijskih lijekova, opisan je njihov mehanizam djelovanja s osvrtom na indikacije i kontraindikacije s obzirom na stadij bubrežnog oštećenja. Cilj rada je pomoći liječniku obiteljske medicine u donošenju ispravne terapijske odluke sukladno postavljenom glikemijskom cilju i stanju bubrežne funkcije.The management of hyperglycemia in patients with chronic kidney disease (CKD) is complex, and the goals and methods regarding glycemic control are not clearly defined. Although aggressive glycemic control seems to be advantageous in early diabetic nephropathy, outcome data supporting tight glycemic control in patients with advanced CKD are lacking. Challenges in the management of such patients include monitoring diffi culties and the complexity of available treatments. In this article, we review the current treatment options for patients with diabetes and CKD discussing all hypoglycemic agents that currently are available, as well as insulin, along with their indications and contraindications. The aim is to provide useful information to family physicians when deciding on individualized glycemic goals and appropriate therapy for patients with early or end stages of CKD

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