Huang, Minren

Pang, Xiaoming

Si, Jingna

Tong, Chunfa

Wang, Zhong

Wu, Rongling

Xu, Meng

Zhang, Bo

BMC Plant Biology

English

PubMed

Abstract
          
            Background
            Genetic mapping has proven to be powerful for studying the genetic architecture of complex traits by characterizing a network of the underlying interacting quantitative trait loci (QTLs). Current statistical models for genetic mapping were mostly founded on the biallelic epistasis of QTLs, incapable of analyzing multiallelic QTLs and their interactions that are widespread in an outcrossing population.
          
          
            Results
            Here we have formulated a general framework to model and define the epistasis between multiallelic QTLs. Based on this framework, we have derived a statistical algorithm for the estimation and test of multiallelic epistasis between different QTLs in a full-sib family of outcrossing species. We used this algorithm to genomewide scan for the distribution of mul-tiallelic epistasis for a rooting ability trait in an outbred cross derived from two heterozygous poplar trees. The results from simulation studies indicate that the positions and effects of multiallelic QTLs can well be estimated with a modest sample and heritability.
          
          
            Conclusions
            The model and algorithm developed provide a useful tool for better characterizing the genetic control of complex traits in a heterozygous family derived from outcrossing species, such as forest trees, and thus fill a gap that occurs in genetic mapping of this group of important but underrepresented species.
          </jats:sec

Chunfa Tong

Bo Zhang

Zhong Wang

Meng Xu

Xiaoming Pang

Jingna Si

Minren Huang

Rongling Wu

Crossref

Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci

Springer - Publisher Connector

Botstein D: Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3377927

Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci

Abstract

Similar works

Full text

Available Versions

Crossref

Springer - Publisher Connector